Yellowhair and colleagues have shown that the pro-inflammatory chemokine (C-X-C-motif) ligand 1 (CXCL1) and its receptor CXCR2 are critical for microglia recruitment and activation in an experimental model of chorioamnionitis, induced by the combination of in utero hypoxia and intra-amniotic inflammation, leading to neuroinflammation and microstructural alterations in the grey and white matter at P15 [95]. Here, CXCR2 is linked to inflammation.