TP53 and thyroid cancer: Moreover, Naseri et al. [21] showed that the antiproliferative effects of R. canina extract against thyroid cancer cells (B-CPAP AND THR.C1-PI 33) was attributed to induction of the apoptotic cell death pathway through increased Bax /Bcl2 proportion together with up-regulating p53 and Caspase 3 expression.