Furthermore, it has been demonstrated that besides its immunomodulatory, pain modulation, anti-diabetic, anti-hyperlipidemic, neuroprotective, genoprotective and antioxidant properties, R. canina displayed a beneficial anti-inflammatory effect by inhibiting NF-κB activation [23, 24] in addition to its anti-cancer and chemotherapeutic effect against different cancer cell lines including colon, lung and prostate [21, 25]. This evidence concerns the gene NFKB1 and cancer.