In conclusion, the current results showed that Rosa synergistically improves the chemotherapeutic potential of cisplatin in lung cancer cells by suppressing the TLR2/MyD88/ TRAF6/NF-κB signal pathway together with the PI3K/AKT/mTOR and Gal-1 which consequently, inhibits proliferation. This evidence concerns the gene NFKB1 and lung carcinoma.