After excluding those younger than 20 years old (n = 1,136), those with a history of CV events at baseline (n = 61), those with missing in PRL data (n = 947), those with PRL > 100 (n = 41), and those without any follow up visit (n = 31), 2005 subjects who followed until phase 7 of TLGS remained for the analyses, CKD and CV events were recorded. The gene discussed is PRL; the disease is chronic kidney disease.