We present two induced models of lung cancer that spontaneously metastasizes using the GEM, KrasG12D+; p53fl/fl; myristoylated p110αfl/fl ROSA-gfp (abbreviated as KPP), developed by Sheen et al.26 The first model, S.KPP model was generated by injecting Ad5SPC Cre virus into the left lung initiating cancer in cells with Surfactant Protein C, specifically alveolar type 2 cells. This evidence concerns the gene SFTPC and cancer.