Another notable observation resulting from our study included upregulation of the calcium voltage-gated channel auxiliary subunit alpha2delta-1 and − 2 (CACNA2D-1 and − 2) proteins in nodal samples as the mutations identified in the CACNA2D-1 gene were previously found in Brugada syndrome patients and in individuals with an early repolarization syndrome53. This evidence concerns the gene CACNA2D1 and Brugada syndrome.