MTREX and HIV-1 infection: A limitation of our study is that, although we were able to demonstrate evidence of the roles of MATR3 and MTR4 in the post-transcriptional regulation of US HIV-1 RNA in co-transfection experiments, in in vitro J-Lat 9.2 cell line model of latency and in primary cell model of HIV-1 infection, their direct roles in post-transcriptional latency and reactivation in primary cell models of latency or PWH cells remain to be established.