This highlighted a series of immune pathways and gene sets whose membership is over-represented at psoriasis risk loci (1632 gene sets at false discovery rate <5%; Supplementary Fig. 11, Supplementary Data 14A); this includes protein-protein interaction subnetworks for the genes CBL (proto-oncogene), EGFR (epidermal growth factor receptor; EGFR signalling being regulated via Cbl39), ESX1 and TEC (Tec Protein Tyrosine Kinase) (Supplementary Data 14B) that are implicated for the first time in this study. This evidence concerns the gene ESX1 and psoriasis.