POU2F3 and psoriasis: A further six putative causal variants were observed in genes located at novel psoriasis susceptibility loci including high-confidence deleterious variants affecting CPVL (ENSP00000387164.1:p.Tyr168His) and POU2F3 (ENSP00000260264.4:p.His154Arg), and a low-frequency nonsense allele in STAP2 that is protective against psoriasis (ENSP00000468927.1:p.Tyr169Ter, CADD score 41.0, OR = 0.79, 95% CI 0.76–0.82) (Fig. 2B).