Studies performed using TC-PTP knockout mice showed its critical role in hematopoiesis and immune function because TC-PTP knockout mice were severely defective in the hematopoietic compartment and all homozygous mice died between 3 and 5 weeks of age due to diarrhea, splenomegaly, lymphadenopathy, and anemia [12]. Here, PTPN2 is linked to Splenomegaly.