In logistic regression analysis, model 1 revealed that ischemic heart disease (OR = 1.539, 95%CI = 1.141–2.077, p = 0.005) and MoCA (OR = 0.957, 95%CI = 0.930–0.984, p = 0.002) was significantly associated with presence of NPS in MCI patients (Table 3). This evidence concerns the gene DOCK3 and coronary artery disorder.