Moreover, the capacity of certain adjuvants to trigger autoimmunity or autoinflammation has resulted in the emergence of the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA).89 Different β-glucans have been used in the past as adjuvants in distinct experimental models of autoimmunity.90–97 Although these earlier studies indicate a link between β-glucan administration and increased inflammation, they did not implicate β-glucan-induced TRIM in this context. This evidence concerns the gene PPIB and autoinflammatory syndrome.