We and others have recently established that the long-term actions of TRIM are linked to rewiring of BM hematopoietic progenitors.24,26,27,29 In this context, β-glucan-induced innate immune training of specific arms of myelopoiesis, e.g., granulopoiesis, leads to potent anti-tumor activity.30 Here, we show that an additional myelopoiesis arm, namely the generation of myeloid precursors of osteoclasts and osteoclastogenesis, is also targeted by TRIM. The gene discussed is TRAT1; the disease is neoplasm.