Although β-glucan-induced TRIM alone (without subsequent arthritis induction) did not affect the frequencies of CD115+CD27high and CD115+CD27low/− OCPs in the BM (Figure 4A), 5 days after K/BxN-STA induction, both populations significantly expanded in β-glucan-trained mice compared with non-trained mice (Figure 4B). The gene discussed is CSF1R; the disease is arthritic joint disease.