As compared with control treatment, MITF inhibition in donor mice blocked the ability of monocytes from β-glucan-trained donor mice to exacerbate arthritis severity in recipient mice (Figures 7C and 7D), as well as to increase expression of the inflammatory cytokines Il6 and Tnf and of the osteoclastogenic transcription factor Nfatc1 in the synovium of recipient arthritic mice (Figure 7E). The gene discussed is TNF; the disease is arthritic joint disease.