The findings concerning the modulation of CCR5 and CX3CR1 are in line with a recent study published by the group,5 in which patients after Acute Myocardial Infarction showed a persistence of the inflammatory phenotype, known as trained immunity, even after the most effective lipid-lowering and antiplatelet treatments. The gene discussed is CX3CR1; the disease is acute myocardial infarction.