Additionally, IL12RB2 was demonstrated that it creates a homeostasis within the tumor cells and tumor-infiltrating lymphocytes and this homeostasis affects prognosis in laryngeal cancer.[28] Pleiotropic cytokine Interleukin 12 (IL-12) has a significant influence in against cancer through Th1 immune response.[29] Therefore, we deduced that IL12RB2 may mediate IL12 to influence Th cells to participate in the cancer resistance. The gene discussed is IL12RB2; the disease is neoplasm.