The IL-12 receptor is composed of the β1 and β2 chains, both of which are needed for high-affinity binding of the cytokine and initiation of signal transduction.[26] The low expression of IL-12RB2 induces to autoimmune disease and cancer.[27]This is match to Figure 5A, IL12RB2 is low expression in high-risk group. The gene discussed is IL12RB2; the disease is autoimmune disease.