CCL4 (OR = 1.131, 95% CI: 1.097–1.233, P = .005) and CXCL6 (OR = 1.313, 95% CI: 1.160–1.489, IVW-FDR P = 1.82 × 10−5) were associated with an increased risk of PCOS. This evidence concerns the gene CXCL6 and polycystic ovary syndrome.