The top 5 keywords in the cluster are “sarcoplasmic reticulum,” “protocorm like bodies,” “plumbagin,” “heart failure,” and “breast cancer.” CiteSpace illustrates the evolution of keywords in different clusters over time, indicating that the focus of PLB research has evolved from “juglone” to “protein kinase a” (Fig. 5A, B). The gene discussed is WEE1; the disease is heart failure.