Based onprevious evidence obtained on Jurkat cells with compound WA-22,11 which significantly regulated cellcycle-regulatory genes and acted as a potent inhibitor of ABCB1, andin light of the antioxidant and neuroprotective properties of compound PPK-32(10) on the in vitro modelof AD, the SH-SY5Y cells, a comparison analysis between the two compoundswas performed. The gene discussed is ABCB1; the disease is Alzheimer disease.