ESR1 and breast cancer: Moreover, immune-staining signals for Ki-67, estrogen receptor (ER), and progesterone receptor (PR) were more intense in tumors grafted with rADSCs than the CM control (detailed methods in Supplementary Information), indicating a higher malignancy grade in hormone-dependent DMBA-induced mammary tumors (Fig. 3E) [19], which was further validated by histological scoring analysis (Fig. 3F).