Mutations in v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) genes, both of which encode receptor tyrosine kinases, are the most common oncodrivers responsible for the development of GIST and are found in 60–85% and 10–15% of these tumors, respectively [1, 3–5]. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.