RB1 and cancer: Through MCODE analysis, we chose the three most important modules (MCODE score = 74.00, 43.38, and 39.129) (refer Fig. 5G, H, I) The MCODE analysis clustered group genes influence ribosomal protein synthesis in cancer cells, linked to dysregulation of key cancer-related proteins like c-Myc, mTOR, p53, pRB, and PTEN, and irregular expression of mitochondrial translational factors [32].