TNF and colorectal carcinoma: Notably, we establish that (i) IL-1β can be a better diagnostic and prognostic biomarker and predicts immune cell infiltration for CRC; (ii) We propose a cyclical regulatory mechanism involving hub genes and regulatory elements that mutually activate and regulate the PI3K/AKT signaling pathway in CRC; (iii) IL-1β, IL-6 and TNF-α expression is associated with inflammatory cell infiltration which can exhibit the progression of CRC.