LEP and myeloid sarcoma: Moreover, leptin, through its signaling pathways and in the context of MS, seems to have a pro-inflammatory role, which aggravate disease progression: in the context of EAE of the mouse model of MS, leptin administered exogenously may be able to aggravate such state, whereas starvation, which produces a significant decrease in leptin levels, may alleviate it (Lord et al., 1998).