Several reported cases show that some individuals experience decreased eGFR and developed proteinuria after receiving anti-VEGF intravitreal injections, and subsequent renal biopsies revealed glomerular pathological abnormalities such as focal segmental glomerulosclerosis, minimal change disease, and thrombotic microangiopathy [30, 31]. The gene discussed is VEGFA; the disease is focal segmental glomerulosclerosis.