Tay-Sachs disease (TSD) is a rare lysosomal storage disorder (LSD) that results from loss-of-function mutations in gene HEXA, which code for the α-subunits of the heterodimeric enzyme β-Hexosaminidase A (Hexa) (Leal et al. 2020). This evidence concerns the gene HEXA and Tay-Sachs disease.