SLs have been found to increase sensitivity to chemotherapeutic agents and reduce resistance to chemotherapeutic drugs through different mechanisms such as inhibition of NF-κB and STAT3 activation and ROS-mediated inhibition in different cancer cells (Fang et al. 2009; Maryam et al. 2017; Wang et al. 2019; Ding et al. 2022). This evidence concerns the gene NFKB1 and cancer.