Piezo1 is known to act together with other TRP channels: in response to pressure overload, Piezo1 transduces mechanical signals to TRPM4 channels in cardiac hypertrophy (Yu et al., 2022), and Piezo1 cooperates with TRPV4 channels in pressure-induced pancreatitis (Swain et al., 2022). The gene discussed is TRPV4; the disease is pancreatitis.