PHGDH and neoplasm: Previous studies have indicated that PHGDH activity is crucial for serine biosynthesis and tumor growth and that high doses of NCT‐503 reduce cell proliferation.[13] The platinum‐resistant cells require exogenous serine for growth.[19] A high dose of NCT‐503 may also disrupt the uptake of exogenous serine or suppress other metabolic processes in resistant cells, which deserves further investigation.