APOE and triple-A syndrome: In Addition, the better aortic structural integrity and less collagen accumulation and elastic fiber breakage in ApoE−/−;Senp3△Mø mice after AngII‐infusion, compared with those in ApoE−/−;Senp3flox/flox mice after AngII‐infusion, were effectively reversed by PAG treatment (Figure 7I–K), suggesting that pharmacological CTH inhibition counteracts the protective effect of SENP3 deficiency on AAA.