APOE and triple-A syndrome: To explore the functional effects of SENP3 on the pathogenesis of AAA, ApoE−/−;Senp3flox/flox and ApoE−/−;Senp3△Mø mice were subcutaneously injected with AngII or saline via osmotic minipumps for 28 days (Figure S6, Supporting Information; Figure 2A).