Notably, we found that the reduced aortic enlargement and reduced incidences of AAA and aortic rupture in ApoE−/−;Senp3△Mø mice after AngII‐infusion in comparison with those in ApoE−/−;Senp3flox/flox mice after AngII‐infusion, were effectively reversed by PAG treatment (Figure 7C–H). This evidence concerns the gene APOE and triple-A syndrome.