SENP3 and triple-A syndrome: For example, CTH deletion exacerbates the progression of AAA and decreased plasma H2S levels are associated with an increased risk of AAA.[26] Deficiency of CTH promotes aortic elastolysis and medial degeneration in aged mice.[44] Inhibition of CTH dampens vasoconstriction in mouse and human intracerebral arterioles.[45] Our research indicated that the protective effects of SENP3 deficiency on ferroptosis and AAA pathogenesis were mediated by CTH signaling.