APOE and triple-A syndrome: To further explore the contribution of CTH signaling to the function of SENP3 in AAA pathology, saline‐ or AngII‐infused ApoE−/−;Senp3flox/flox and ApoE−/−;Senp3△Mø mice were treated with PAG, a selective inhibitor of CTH, at a dose of 50 mg kg−1 day−1 for 28 days (Figure 7A).