Moreover, we found that PAG treatment exacerbated aortic enlargement (Figure 7C–F) and increased the incidences of AAA and aortic rupture (Figure 7G,H) in ApoE−/−;Senp3flox/flox and ApoE−/−;Senp3△Mø mice after AngII‐infusion. The gene discussed is APOE; the disease is triple-A syndrome.