In Addition, the better aortic structural integrity and less collagen accumulation and elastic fiber breakage in ApoE−/−;Senp3△Mø mice after AngII‐infusion, compared with those in ApoE−/−;Senp3flox/flox mice after AngII‐infusion, were effectively reversed by PAG treatment (Figure 7I–K), suggesting that pharmacological CTH inhibition counteracts the protective effect of SENP3 deficiency on AAA. This evidence concerns the gene CTH and triple-A syndrome.