Our study revealed a reduction in the protein expression of CTH in human aneurysm tissues relative to non‐aneurysmal tissues (Figure 5B), aligning with existing literature.[26] Consistently, CTH protein level was significantly decreased in aortic tissues from ApoE−/−;Senp3flox/flox after AngII infusion (Figure 5C). This evidence concerns the gene APOE and aneurysm.