FASN and Alzheimer disease: Additionally, as previously mentioned, the R1819W mutation in FASN can lead to cognitive impairments in patients who are diagnosed with AD.[23] Furthermore, in another study on AD patients, we found that some patients carry the V2005A point mutation in FASN.[35, 54] Although the significance of this mutation is not high due to the limited cohort size, it also suggests the possibility that FASN point mutations can cause cognitive impairments.