CGAS and neurodegenerative disease: A multitude of studies have underscored the DNA‐sensing cGAS‐STING pathway as a pivotal neuroinflammatory axis, integral to the pathogenesis of a spectrum of neurodegenerative diseases, such as PD, HD, AD, and ALS.[55] The nucleus‐derived cytoplasmic formation of chromatin fragments (CCFs) and activation of retrotransposons could activate the DNA‐sensing cGAS–STING pathway.[56] Here we demonstrated that damaged mtDNA triggered by disorders of lipid metabolism, not genomic DNA, activated this pathway, mediating the crosstalk between neurons and microglia in NDs.