The studies from Wyss‐Coray's laboratory found that microglia in aged mouse brains or in Alzheimer's disease patients accumulated LDs to form more LD‐loaded dysfunctional microglia termed LD‐accumulating microglia (LDAM); the LDAM are inflammatory and release factors to induce Tau phosphorylation and neurotoxicity in neurons.[9, 10] Interestingly, another ND protein, alpha‐synuclein (α‐Syn), also interacts with LDs and activates an inflammatory pathway. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.