Notably, METTL3‐mediated m6A methylation promotes liver fibrosis by enhancing the secretion of TGF‐β.[29] Additionally, the highly specific small‐molecule inhibitor of METTL3, STM2457 (Chemicals, DC53045, Shanghai, China), has been shown to attenuate kidney fibrosis in vivo.[30] However, the relationship between RNA modifications and skin fibrosis remains unclear. This evidence concerns the gene TGFB1 and Hepatic fibrosis.