Alternatively, autologous antigen vaccines work by expanding antigen‐specific CD4+CD25+ Treg cells, which leads to either T cell deletion or anergy, thereby aiding in the prevention of type 1 diabetes onset.[20] Currently, insulin injection is still the main treatment for type 1 diabetes.[21, 22] Intriguingly, oral sustained‐release insulin nanoparticles exhibit the capacity of reduce blood glucose levels and demonstrate favorable therapeutic effects.[23, 24, 25]. Here, CD4 is linked to type 1 diabetes mellitus.