Saha et al. (2024) found that CD45-ADC conditioning followed by transplantation of fully allogeneic BM significantly increased survival and reduced aGVHD compared to that in Fanconi anemia mice that received lethal TBI and allogeneic HSCT. In addition, these investigators reported that administration of anti-human CD45-ADC to Rhesus monkeys (Box 1) produced robust myeloablation that was similar to that produced by lethal TBI (Saha et al., 2024). The gene discussed is PTPRC; the disease is Fanconi anemia.