To identify biomarkers for preventing postoperative tumor recurrence and key targets to extend the RFS time of patients with HCC, seven biomarkers (PFN2, PLOD2, CDC20, CCT5, TALDO1, HDGF, and FTCD) associated with tumor postoperative recurrence were successfully screened using multiple machine learning analysis methods. Here, TALDO1 is linked to hepatocellular carcinoma.