To identify biomarkers for preventing postoperative tumor recurrence and key targets to extend the RFS time of patients with HCC, seven biomarkers (PFN2, PLOD2, CDC20, CCT5, TALDO1, HDGF, and FTCD) associated with tumor postoperative recurrence were successfully screened using multiple machine learning analysis methods. This evidence concerns the gene PLOD2 and neoplasm.