Finally, we also discovered that there were differences in the number and types of cellular interaction signaling pathways within the microenvironments of early‐relapse and primary tumors (Fig. 2G), where unique ligand‐receptor signaling pathways in early‐relapse tumors (including TIGIT and HSPG) might play a key role in the recurrence process of HCC. Here, TIGIT is linked to hepatocellular carcinoma.