[82] collaborated in their single‐cell RNA sequencing of tumors from ESCC patients undergoing neoadjuvant immune checkpoint blockade (ICB), which revealed a subpopulation of depleted CD8+ T cells expressing SPRY1, which exhibited a progenitor‐depleted T‐cell (Tpex) phenotype and were associated with a response to ICB complete response [83]. Here, SPRY1 is linked to esophageal squamous cell carcinoma.