Through a cluster of cluster assignments (COCA) analysis [69], ESCC was classified into four distinct molecular subtypes: cell cycle signaling activation (CCA) subtype, NRF2 oncogenic activation (NRFA) subtype, immunosuppression (IS) subtype, and immunomodulation (IM) subtype. The gene discussed is NFE2L2; the disease is esophageal squamous cell carcinoma.