A total of 633 FH patients with genetically confirmed LDLR mutations from 2 independent FH centers (Beijing Anzhen Hospital and Peking University First Hospital) participated in this study, containing 181 patients with HoFH (male, 52.5%) and 452 subjects with HeFH (male, 51.3%). The gene discussed is LDLR; the disease is familial hyperaldosteronism.