In the Deregulated CDK5 Triggers Multiple Neurodegenerative Pathways in Alzheimer’s Disease (R-HSA-8862803.4) pathway, it interacts with YWHAE (14–3-3ε), stabilizing the cytoskeleton and modulating stress responses (Cho et al., 2022). The gene discussed is YWHAE; the disease is early-onset autosomal dominant Alzheimer disease.