CD117+/CK7+ (diffuse, uniform), as well as E-cadherin and N-cadherin + reactivity, raisinoid nuclei of varied size with “halo” surroundings, and multiple, recurrent chromosomal losses (e.g. 1, 2, 6, 10, 13, and 17) that are more suggestive of eo-ChRCC [4,5]. Vimentin and carbonic anhydrase IX (CA-IX) are generally negative in RO and eo-ChRCC [4-6]. The gene discussed is CDH2; the disease is chromophobe renal cell carcinoma.