Diagnosis of varicella and zoster is most often made clinically on the basis of the characteristic generalized or unilateral dermatomal vesicular rashes, respectively [5]. Although arterial thrombosis is common in VZV, venous thrombosis is rare and may result from a similar mechanism as arterial thrombosis or acquired protein S deficiency, typically occurring after a latent period of two to three weeks, during which autoantibodies to natural anticoagulants develop, triggering widespread thrombosis. The gene discussed is PROS1; the disease is Venous thrombosis.