CLCN7 and osteopetrosis: In this study, we found that 10 metabolites including PGG2, Delta-12-prostaglandin J2 (D12-PGJ2), 15-KETE, PGB2, 6-Ketoprostaglandin E1, 13-oxo-ODE, LOOH, phosphorylcholine, acetylcholine and glycerophosphocholine, were significantly down-regulated in osteopetrosis patients caused by CLCN7 mutation.