Research indicates that JNK signaling activation occurs in animal models of depression (Adzic et al., 2009; Egeland et al., 2015; Rogatsky et al., 1998) and that inhibition of the JNK pathway leads to increased neurogenesis and alleviation of depressive and anxiety-like behaviors (Mohammad et al., 2018). This evidence concerns the gene MAPK8 and depressive symptom measurement.