For example, introduction of HIV-1 Tat and gp120 to cells of the HPV-16-infected cervical cancer SiHa cell line led to the induction of EMT and cell migration and invasion secondary to the activation of the Wnt/β-catenin pathway (132), indicating that the Tat/gp120-activated Wnt/β-catenin signaling pathway also contributes to EMT progression (132). The gene discussed is ITIH4; the disease is cervical carcinoma.