We constructed a competing endogenous RNA (ceRNA) regulatory network and identified the lncRNA SNHG16/hsa-miR-30b-5p/LARP1 and lncRNA LINC00707/hsa-miR-30b-5p/LARP1 regulatory axes as being related to HNSCC patient prognosis. This evidence concerns the gene LARP1 and head and neck squamous cell carcinoma.