For instance, the abnormal activation of PI3K/AKT, mTORC1, ERK/MAPK, STAT3/5, IDH2, Wnt/β-catenin, and NF-κB pathways are linked to the relapse and pathogenesis of cancer such as acute myeloid leukemia (Park et al., 2010; Fadeev et al., 2015; Gruszka et al., 2019; Dai et al., 2021). The gene discussed is IDH2; the disease is acute myeloid leukemia.