The first tubulin gene associated with impaired cerebral cortical development was TUBA1A, a key gene regulating the synthesis of α-tubulin, and its variants affect the folding of tubulin heterodimers and the interaction of microtubule-binding proteins, resulting in microtubule dysfunction and neuronal progenitor cell motility defects, which are related to lissencephaly combined with cerebellar atrophy (9). This evidence concerns the gene TUBA1A and Cerebellar atrophy.