The first tubulin gene associated with impaired cerebral cortical development was TUBA1A, a key gene regulating the synthesis of α-tubulin, and its variants affect the folding of tubulin heterodimers and the interaction of microtubule-binding proteins, resulting in microtubule dysfunction and neuronal progenitor cell motility defects, which are related to lissencephaly combined with cerebellar atrophy (9). Here, TUBA1A is linked to lissencephaly spectrum disorders.