After adjusting for age, sex, education level, marital status, BMI, dyslipidemia, heart disease, stroke, smoking status, drinking status, lipid-lowering drugs, hypoglycemic drugs, HbA1c, and CRP, the proportion of mediators of eGFR was elevated (Adjusted for 6.00% vs. 3.14%) (Supplementary Figures 3A, B). The gene discussed is CRP; the disease is heart disorder.