prepared AuNDs@aPD-1, which not only exhibits long-term retention of drugs and enhancing the tumor-targeting ability, but also efficiently promotes the activation of antitumor CD4+ and CD8+ T cells, and inhibit the Treg cells activity in tumor when combined with PTT, showing significant anticancer ability to local as well as distant tumors (Figures 2C, D) (He et al., 2022). This evidence concerns the gene CD4 and neoplasm.