More importantly, the CD8+ T and CD4+ T cells in distant tumors were significantly activated in distant tumor when WO2.9-WSe2-PEG nanoparticles combined with RT/PTT and anti-PD-L1 antibody, indicating powerful immunological memory-killing and efficiently antimetastatic and anticancer effect (Figure 9B). The gene discussed is CD8A; the disease is neoplasm.