When the coronary blood supply is inadequate, the myocardium receives insufficient oxygen and nutrients, Hypoxia-inducible factor-1α (HIF-1α) has an essential role in ventricular remodeling processes involving myocardial fibrosis and hypertrophy (17), prompting the myocardial cells to undergo physiological hypertrophy as an adaptive response to the hypoxic environment. Here, HIF1A is linked to Myocardial fibrosis.