Hypovolemic shock; HF (EF <30%); CKD (SCr >2 mg/dL); thyrotoxicosis; pheochromocytoma; CMO; DDI (MAOIs, alpha-1 blockers, TCAs); orthostatic hypotension; bradycardia (HR <50 bpm); MID PTA; NPO; allergy. This evidence concerns the gene PSMA6 and allergic disease.