We have recently introduced Warburg subtyping (Warburg‐low, Warburg‐moderate, and Warburg‐high), based on the expression levels of six glycolytic proteins and transcriptional regulators indicative of the presence of the Warburg effect (GLUT1, PKM2, LDHA, MCT4, p53, and PTEN), as a promising novel prognostic [24] and predictive [36] marker in CRC patients. This evidence concerns the gene PTEN and colorectal carcinoma.