Moreover, many genes involved in hepatic PUFA and phospholipid metabolism are important in the formation of biologically important lipids and are linked to metabolic disease by human GWAS and mouse knockout studies, for example, FADS1, ELOVL5, LPCAT3, MBOAT7, CEPT1, PLA2G4A/cPLA2α, PLA2G6/iPLA2β, PTGDS and PTGES (Jalil et al., 2019; Zhang et al., 2016). This evidence concerns the gene ELOVL5 and metabolic disease.