HFD‐induced obesity also upregulated Hsd17b11 and Hsd17b7 hepatic gene expression in C57BL/6J mice and fenretinide treatment decreased their gene expression compared to HFD mice (Figure 2a RNA‐seq mini‐table Hsd17b family of genes). This evidence concerns the gene HSD17B11 and obesity due to melanocortin 4 receptor deficiency.