However, our RNA‐seq revealed that HFD‐induced obesity in C57BL/6J mice for 20 weeks did induce increased expression of genes driving fibrosis and tissue remodelling, for example, collagens (Col1a1, Col12a1 and Col15a1), tissue inhibitors of matrix metalloproteinases (Timp1 and Timp2) and canonical Yap/Taz signalling pathway (Wwtr1 and Ctgf) (GEO number GSE220684 and data available on request). The gene discussed is CCN2; the disease is obesity due to melanocortin 4 receptor deficiency.