HSD17B13 and obesity due to melanocortin 4 receptor deficiency: In the present study, our analysis of unbiased, whole‐genome RNA‐sequencing in liver tissue from mice with high‐fat diet (HFD)‐induced obesity and type‐2 diabetes and mice treated with fenretinide to inhibit MASLD (Mcilroy et al., 2013; Morrice et al., 2017) revealed genes that are key drivers of MASLD including peroxisome proliferator‐activated receptor α (PPARα) targets, lipid‐droplet proteins (e.g. Hsd17b13), pro‐fibrotic genes and phospholipid metabolism genes.