Additionally, AMP-activated protein kinase (AMPK) activation-induced phosphorylation of PDZD8 at threonine 527 (pT527) is required for the increased utilization of glutamine (glutaminolysis) in response to hypoglycemia [10], and consequently for the extension of healthspan and lifespan induced by calorie restriction [11]. Here, PDZD8 is linked to Hypoglycemia.