PDZD8 and type 2 diabetes mellitus: In pancreatic islet tissue of a HFD-induced mouse model for T2D, increased levels of ER stress markers and signs of mitochondrial dysfunction (e.g., oxidative stress, ATP depletion), together with enhanced Pdzd8 transcript and mitochondria–ER contact levels, were alleviated by Pdzd8 knockdown [78].