PDZD8 and type 2 diabetes mellitus: A recent study of C57BL/6J mice fed a high-fat diet (HFD) showed that type II diabetes (T2D)-related phenotypes, including insulin resistance and pancreatic β-cell death, are accompanied by upregulation of Pdzd8 mRNA levels in pancreatic islet tissue, but these effects were alleviated by knockdown of Pdzd8 via systemic AAV9-mediated shRNA [78].