PDZD8 and hyperinsulinemic hypoglycemia, familial, 4: These findings suggest that the obesogenic effects of leptin deficiency and HFD feeding may be attenuated by a reduction in PDZD8 levels, although the hepatic lipid content of 3-month-old Pdzd8em1Kei mice fed either a normal diet or a high-fat diet was not substantially different from that of WT controls [33].