The results showed that in the TCGA lung adenocarcinoma dataset, the expression levels of MMP1, IL23A, MMP3, ATP6V1C2 and CCL20 were significantly higher than those of the control group (P < 0.001), while the expression levels of other genes were significantly lower than those of the control group (P < 0.001, Fig. 10A). The gene discussed is MMP1; the disease is lung adenocarcinoma.