In lung adenocarcinoma, high expression of CCL20, IL23A, MMP1 and MMP3 was significantly associated with poor patient prognosis, whereas high expression of FOS, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1 and HLA-DRA was significantly associated with improved patient prognosis. The gene discussed is HLA-DQB1; the disease is lung adenocarcinoma.