CCAS can also be seen in complex cerebrocerebellar pathological conditions, such as cerebellar and brainstem hemorrhage, complex cerebrocerebellar degeneration with gene variants (senataxin, gene, and X-linked recessive ATP2B3 gene), pontine cavernous malformation, ataxia with oculomotor apraxia type 2 (AOA2), Friedreich’s ataxia, SCA1, SCA2, SCA3, SCA7, SCA17, and multiple system atrophy of the cerebellar type (MSA-C) [9]. Here, CASP3 is linked to multiple system atrophy, cerebellar type.